The 23-year-old suffered a head knock during the Lions QClash victory over Gold Coast, placing him in the league's mandatory 12-day concussion protocols period.
Payne has been having a career-best season, establishing himself as one of the improved intercept markers in the competition.
In welcome news for the in-form Lions, damaging half-back Daniel Rich will return for the clash against the Crows. Rich has missed the last three matches due to a calf injury sustained against Fremantle in Round 7.
Meanwhile, Keidean Coleman will be closely monitored this week after experiencing glute soreness during the Suns game.
Brisbane's injury list has taken a hit with hard nut Rhys Mathieson (hamstring) out for up to six weeks, forward Shadeau Brain (shoulder) and defender Noah Answerth (concussion), all hurt in the Lions' 117-point demolition of Coburg in the VFL.