West Coast will be without premiership pair Luke Shuey and Shannon Hurn for this weekend's venture to Vulture Street, with the duo unable to get through training due to soreness.

Coach Adam Simpson confirmed an array of personnel changes will be made for his side's trip to face Brisbane, with two of his oldest generals to be among the omissions.

After being tested at training this week off the back of a promising performance against St Kilda on Sunday, both Shuey and Hurn pulled up sore and, due to entering the six-day turnaround with an interstate trip, won't be risked at selection.

The pair of outs will be combated with the returning Jeremy McGovern and Tim Kelly, with the latter a late omission for the Saints game due to illness.

The Eagles will regain McGovern for his first game since Round 3 following a hamstring injury, while Luke Edwards will also be in the mix after recovering from his own illness.

Key forward Jack Darling will be named despite sustaining a sore shoulder last weekend, while defender Tom Cole will make his return from an ankle injury that has kept him sidelined since April.

Cole will be named as the tactical sub as part of the group of travelling emergencies, with West Coast's WAFL side to include just the two AFL-listed players for another week.

West Coast, who are on a 13-game losing run, will take on the third-placed Lions at the Gabba at 1:45pm local time on Saturday.