Richmond are confident in having senior trio Dustin Martin, Trent Cotchin and Dylan Grimes back for Sunday's clash with St Kilda, while defender Daniel Rioli is no certainty of suiting up for the must-win encounter.
Both Martin and Cotchin were unable to play in last Friday's loss to the Western Bulldogs due to soreness, having been unable to back up their outings against Melbourne the week prior due to the short turnaround.
Grimes was a late withdrawal from the Bulldogs match due to a neck injury which cause the Tigers co-captain issues on matchday before as he dealt with a pinched nerve.
On Monday, Richmond physical performance manager Luke Meehan revealed both Martin and Cotchin are likely to be available for Round 22, while Grimes is a test for the upcoming weekend.
"Dustin is such a dynamic and explosive player, but he unfortunately could not get himself going last week, so he was unavailable for selection," Meehan said in a club update.
"The accumulative load of the season and the five-day turnaround, at this late part of the year, was just a bit too much for him in the end. He is in better condition now and will train this week ahead of playing on Sunday.
"Like Dustin, the five-day break for Trent with a few niggles, was just a bit too much to overcome. He has freshened up and will be available to play on Sunday.
"Dylan woke up on Friday morning with a stiff neck that was causing him quite a lot of discomfort. We got him scanned and it was apparent he had pinched a nerve in there and that it would be best that he was a late withdrawal from the match.
"Dylan has seen great improvement over the weekend and is in a position now that he can train this week with an eye to returning to the lineup on Sunday."
Rioli will be eased into a lighter workload to start this week after suffering an ankle injury against the Bulldogs. The Tigers defender was able to play out the match but has pulled up sore since.
Meehan said Rioli is a live chance to face St Kilda thanks to the lengthy turnaround between games.
"Daniel hurt his ankle late in the first quarter of Friday night's game with the Dogs which needed to be treated and re-strapped during the match," Meehan said.
"He was able to get through the game but as expected pulled up a bit sore. He will have a lighter start to the week, but we are hopeful he will join in main training and be available to play on Sunday. The nine-day break will certainly help Daniel's chances of getting up and we have a level of confidence that he will be able to do so."
Small forward Maurice Rioli Jnr is also in selection consideration after overcoming a concussion sustained at training before Round 20, while star midfielder Jacob Hopper and fringe swingman Ben Miller have both entered concussion protocols after suffering head knocks at AFL and VFL level respectively.
Lastly, young forward Judson Clarke won't return this season after suffering a cracked scapula in the VFL against Williamstown over the weekend.
Meehan revealed the "nasty injury" won't require surgery, but will spell the end of Clarke's second season at Punt Road.
"Unfortunately, Judson had quite a nasty injury in the VFL game at Williamstown on Sunday," Meehan said.
"Judson has a cracked scapula and that will unfortunately end his season. He does not need surgery, but the healing process will be pretty slow and see him not involved in any contact work for a few months.
"It has been a great season for Judson so it's a shame that it has ended prematurely but one thing we know with him is that he will keep himself in great condition and be raring to return to full training for the 2024 season."
Richmond's senior side will face St Kilda at Marvel Stadium on Sunday at 3:20pm (AEST).