While the Eagles will require further examination of the ailment, scans have shown a minor fracture in Edwards' wrist that will keep the 22-year-old sidelined.
Bazzo will join Zane Trew, Luke Foley and Connor West as emergencies for Sunday's match at Adelaide Oval, with Simpson to select one of the quartet as his side's tactical sub one hour prior to the 12:40pm (ACST) bounce.
The Eagles have also revealed young forward Isiah Winder has been sidelined with a knee injury, an ailment that will keep the West Coast goalsneak out of action for this week's action at the WAFL level.
Winder reported knee soreness to the club earlier this week and has since been withdrawn from playing duties, with the club hoping to have a greater grasp on the full extent of the setback in the coming days.
West Coast's reserves are scheduled to face West Perth on Saturday afternoon.