Unbeaten St Kilda may sit atop the league's ladder after eclipsing Essendon by 18 points at the MCG on Saturday night, however, their 3-0 start has been soured ever so slightly with another pair of Saints added to the club's already mammoth injury list.

The Saints celebrated their 150th anniversary in style, running away with the contest in the final term after being tested before 69,255 fans.

But with defender Jimmy Webster and the white-hot Mason Wood going down with separate injuries, there are now a staggering 15 players deemed unfit for action at Moorabbin.

Returning after suffering a broken hand, Webster was in the wars again during the Saints' third win on the bounce after colliding with fellow backman Dougal Howard, causing the Tasmanian to nurse a cheekbone complaint.

Speaking in the aftermath of the three-goal win before St Kilda's largest home-and-away attendance at the 'G, head coach Ross Lyon confirmed initial suspicions.

"My understanding is (Webster's) cheekbone is under a little bit of pressure," he said.

After throwing his name into early All-Australian contention after the first three rounds, Wood was struck down with a shoulder complaint, however, the former Roo was able to play out the game.

"Mason Wood's got a bit of a shoulder, but again we'll assess it in the cold light of day," Lyon stated.

"It's not ideal. Jimmy's definitely out with a cheekbone but Mason we'll assess tomorrow."

Speaking on the Channel 7 broadcast while clad in a sling, Wood offered an honest appraisal of his ailing joint.

"It's not a good AC joint (injury), to put it that way. How bad? We're not sure" Wood divulged.

"(The) doc' wasn't super pumped about it, so it might be a bit of time on the sidelines."

Wood's reprisal as a footballer throughout 2023 has been both marked and irrefutable, with the 29-year-old averaging 23.7 touches each week and hitting the scoreboard at better than a goal a game.

Both Webster and Wood are now set to join the sidelined crew of Jack Bytel (knee), Tim Membrey (knee), Jack Steele (collarbone), Nick Coffield (calf), Jack Billings (leg), Isaac Keeler (knee), Max King (shoulder), Jack Hayes (foot), Olli Hotton (back), Daniel McKenzie (calf), Zak Jones (Achilles), Matthew Allison (foot) and Angus McLennan (back).

The undefeated Saints will earn their next chance to march in when they face Gold Coast at Marvel Stadium next Saturday night.