West Coast have come away from Sunday's Western Derby loss with as many as seven injuries, a toll that includes likely extended spells on the sidelines for multiple key players.

The Eagles were valiant in their defeat to arch-rivals Fremantle, having lost their entire interchange by the final quarter to see their inspired comeback wane in the fourth term.

Luke Shuey (hamstring), Jeremy McGovern (hamstring), Jamie Cripps (ankle), Alex Witherden (concussion) and Liam Ryan (knee) were among those sidelined during the 41-point loss, while the latter was able to play out the match despite a nasty fall in the third quarter.

Cripps was hospitalised with a suspected broken ankle in what is a cruel blow for the veteran forward, while Shuey and McGovern are also set to face lengthy periods out of action with hamstring concerns.

Witherden will enter concussion protocols and miss West Coast's Round 4 clash with Melbourne, while further injuries could be confirmed by the club in the coming days.

"I think we're probably going to lose six or seven players from today," West Coast coach Adam Simpson said after the loss.

"I said to them at three-quarter time, in juniors you don't want to come off, well that's happening this quarter.

"In the end, we got overwhelmed. They were a better side and I tip my hat to Fremantle ... but we'll take some real positives."

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The Eagles could welcome the return of midfielder Elliot Yeo to face Melbourne next Sunday in what will be a timely boost for Simpson's side, who now sit 1-2 following the loss to Fremantle.

The club confirmed days prior to their Round 3 defeat that ruckman Nic Naitanui will likely be sidelined for the first half of the season due to an ongoing Achilles issue.

West Coast are scheduled to face the Demons at Optus Stadium next Sunday, with the match to commence at 3:20pm local time.