With illness sidelining Mitchell for this weekend's fixture, Macdonald has earned a call-up for his maiden match in the brown and gold.
Macdonald joined the Hawks from the Oakleigh Chargers as the 51st selection in las year's draft, with his speed and ball-carrying abilities a highlight.
“Bailey has continued to impress us since walking through our doors post his selection at Pick 51 in the 2022 national draft,” Hawks football bos Rob McCartney said.
“His determination to improve has been evident, he is a humble and hard-working individual, and this has translated into consistent performances at VFL level.
“Bailey possesses some really dangerous weapons, with genuine speed and a willingness to attack from the back half with ball in hand.
“First games are always special occasions for our club, and we can't wait to celebrate our fifth debutant for season 2023.”
Macdonald was a shining light for the Hawks across his first pre-season, with the teenager going on to average 16.9 disposals and 4.8 marks per game for Box Hill in the VFL so far this season.
Teammate James Worpel labelled Macdonald as "the quickest man ever" just months into his tenure at the Hawks.
"I think Bailey Macdonald has looked pretty good off half-back which is nice," Worpel said toward the end of the club's pre-season program when speaking to Zero Hanger.
"He's the quickest man ever so good luck catching when he gets the footy."