Fremantle vice-captain Caleb Serong is out of his side's Friday night clash against St Kilda with a calf injury.
The star Dockers midfielder is expected to miss between 2-3 weeks with the injury, including fixtures against Brisbane at the Gabba and North Melbourne at Hands Oval in Bunbury.
Serong joins captain Alex Pearce (knee), ruck Sean Darcy (calf) and midfielder Hayden Young (concussion) as key Dockers on the sidelines.
Serong will be replaced by midfielder Corey Wagner who has recovered from an injury to his adductor.
The Saints have their own slew of injuries with the likes of Nasiah Wanganeen-Milera (calf), Max King (hamstring), Mitch Owens (calf), Jack Higgins (knee) and Liam Ryan (calf) all missing.
St Kilda confirmed on Thursday that Higgins had minor surgery on his knee which he injured in Round 10. The club said its star forward will miss a "short period" of time with the injury.
Veteran Mason Wood returns to the side in place of Higgins after a strong return against Casey in the VFL, netting 28 disposals and booting three goals.
In other big injury news, Carlton key defender Jacob Weitering will miss his side's match against Port Adelaide on Saturday with calf tightness. Rookie Wade Derkson comes into the team for Weitering.
Fellow Blues Zac Williams (managed) and Ollie Hollands (injured) will also miss the game at Adelaide Oval.
Maligned Essendon key defender Ben McKay will return to the side for the Dreamtime at the G fixture against Richmond on Friday night after a few games in the VFL.
Collingwood skipper Darcy Moore, ruck Darcy Cameron and midfielder Patrick Lipinski will join incumbent V/AFL games record holder Scott Pendlebury in returning for the Pies for their match with West Coast on Saturday.
