Brander was not offered a new deal by the Eagles for next season after the club kept their options open for the 22-year-old throughout the recent exchange window.
Eagles CEO Trevor Nisbett flagged that Brander's services would be on the table during the trade period, with few suitors emerging.
The versatile tall played 11 matches in the blue and gold this season, failing to cement his place in Adam Simpson's side in a campaign that saw his contract at Lathlain Park come to an end.
Greater Western Sydney have shown interest in bolstering their ready-made depths this off-season, with Brander among several names understood to be on their list.
Now, the Giants are set to swoop on the Victorian following the commencement of the delisted free agency period, with Brander having originally been a member of the club's Academy.
The Giants released a statement on Monday confirming their interest in Brander ahead of the delisted free agency period.
"Brander is a former GIANTS Academy member and would be returning home after 22 games with the West Coast Eagles."
From November 3 clubs will be able to recruit delisted free agents for one week before a first list lodgement on November 10. Clubs will then have until November 15 to recruit any further players via the delisted free agency.
Brander has played 22 games for the Eagles since arriving in Perth via the 2017 National Draft as the 17th overall selection.