According to 7 News Perth's Ryan Daniels, Brander is likely to make a move east, with a return to Victoria potentially on the cards.
The 22-year-old's departure is a likely outcome of the Eagles' tight salary cap situation, which has placed a number of key players without deals for next year.
It was understood that both the Eagles and Vardy were keen to continue their partnership, however financial difficulties look to have brought the ruckman's tenure in blue and gold to an end, with the 30-year-old announcing his retirement.
Now, Brander looks destined to be the next name heading for the exit, with the Eagles reportedly open to a trade should a keen rival come calling.
Jarrod Brander has not been offered a new contract by @WestCoastEagles.
The 22-year-old former 1st rounder is preparing to move east. The Eagles will look to facilitate a deal in the upcoming trade period, if there's interest. If not, Brander will head to the draft.@7NewsPerth
— Ryan Daniels (@FootyRhino) September 18, 2021
The Cats have been closely linked to Brander's services given his upbringing at Geelong Grammar, while other Victorian clubs are tipped to show interest.
Speaking on ABC Radio earlier this week, Eagles chief executive Trevor Nisbett stated that Brander would be available to offers.
"We'll get through the trade period with Jarrod and then we'll make some decisions on Jarrod as to where he's at," Nisbett said.
"Currently we're waiting on the trade period to start.
"If Jarrod is a tradable player, we'll see if someone's got some interest in Jarrod.
"After that we'll see what happens from that point on, but we'll make decisions post the trade period."
Brander joined the Eagles as a first-round selection in the 2017 National Draft and played 11 games for the Eagles in 2021, doubling his career tally.