Giants star Toby Greene is expected to miss four weeks with a shoulder injury, reports Fox Sports' Tom Morris.
The report also states that the Harry Perrman will miss multiple weeks after suffering a hamstring injury.
The club could confirm the news as early as Monday morning in a cruel blow for Leon Cameron's side.
Greene had been enjoying arguably a career-best season, especially since taking over the captaincy reigns from injured incumbent Stephen Coniglio - averaging 18.7 disposals and booting 22 goals.
The star forward recently added an extra two seasons to his contract until 2026, effectively making him a Giant for life.
Meanwhile, Perryman has also been one of GWS' best players in 2021, averaging 22.7 disposals from six games.
The Giants coming off a narrow four-point loss to Richmond on the weekend to currently sit ninth on the ladder.
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