The Bulldogs are searching for their first win of the season after falling to the Demons in Round 1, a match that saw coach Nathan Burke lose jet forward Isabel Huntington for the season due to an ACL injury.
Now, as revealed AFLW reporter Sarah Black, Blackburn will join Huntington - among several other key names - on the sidelines for the Dogs' second encounter of 2022.
Burke was able to name just the two emergencies for the Melbourne loss, with their arch-rivals coming away victors to the tune of 24 points at Whitten Oval.
Huntington's absence in attack is set to be greatly felt throughout the remainder of the year, with the Dogs already looking to fill gaps in their rearguard with Hunt and Lynch unable for selection.
With Blackburn now set to be removed from midfield planning for this weekend, further concerns grow for Burke and co.
The reigning Bulldogs best and fairest winner backed up a strong 2021 campaign with 21 possessions, 386 metres gained, seven tackles and five inside 50s in her side's season opener.
Geelong will host the Bulldogs at GMHBA Stadium at 7:10pm Saturday, with both clubs eager to claim their first handful of premiership points for the season.