Brown was recruited out of Tea Tree Gully and SANFL side Norwood, joining the Crows from the Giants as a pre-listed player in 2011.
The versatile defender offered a reliable service to the Crows, solidifying his spot in his second season with the club and playing over 20 games across six successive seasons.
Brown would also feature in the club's grand final finish against Richmond in 2017, and played 11 games this season, with a knee injury curtailing his campaign.
The 181-centimetre defender said he was happy with his decision to hang up the boots, a move on his mind for some time.
“I’d like to thank the club for the journey, I’ve spent a third of my life here and with a young family I am now ready for the next chapter,” Brown said in a club statement.
“I remember being overlooked in my draft year in 2010 and to be given the chance to play AFL in my home state the year after is something I was very grateful for.
“So to be here 11 years and 189 games later is something I’ll forever be proud of.
“My first game was memorable as were all the finals I got to play in, and as disappointing as the grand final in 2017 turned out to be, to have that opportunity at the top level is something I will always cherish.
“I’ll leave with lifelong friendships and always be proud to have played my career at the Adelaide Football Club.”
Brown is the first player to have departed Adelaide this year, with the club yet to confirm any further list calls ahead of 2023.