Star Magpies defender Jeremy Howe will miss the majority of the rest of the season after suffering a hamstring setback, as first reported by The Age's Michael Gleeson.

The report states that the high-flyer will require surgery after aggravating scar tissue in his hamstring during a training session on Saturday.

Collingwood has since confirmed the unfortunate injury news.

“Jeremy trained exceptionally well last Thursday and all the signs were that he would return against Sydney this week,” Collingwood GM of Football Graham Wright told collingwood.fc.com.au. 

“But on the weekend he felt a grumble and we decided to have him re-examined today. Jeremy is understandably disappointed. He put so much work into recovering from a serious knee injury in 2020 and to lose a significant part of another season hurts.”

Howe initially suffered the injury during his side's loss West Coast in Round 4 and had been pushing for a senior return this week.

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But is now places his season in doubt in a major blow for Collingwood amid a horrendous 2-6 start to 2021, currently sitting 16th on the ladder after Saturday's win against the Kangaroos.

Howe missed most of the 2020 season after requiring knee surgery to repair his PCL and MCL. He joins Taylor Adams (MCL) and Jamie Elliott (ankle) on Collingwood's long-term injury list.

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The ex-Demon, who turns 31 later this year, has played 192 AFL games since making his debut in 2011.

In further bad news for the Magpies, Jordan Roughead and and Nathan Murphy both won't play this week after suffering concussions against North Melbourne.

The Pies will be searching for their third win in 2021 when they face the Swans at the SCG on Saturday at 1.45pm AEST.