PERTH, AUSTRALIA - SEPTEMBER 10: Patrick Dangerfield of the Cats reacts after being defeated during the AFL First Preliminary Final match between the Melbourne Demons and Geelong Cats at Optus Stadium on September 10, 2021 in Perth, Australia. (Photo by Paul Kane/Getty Images)

Geelong midfielder Patrick Dangerfield will be hopeful his latest setback won't further hinder his 2022 season, with the veteran Cat suffering a calf complaint.

Dangerfield was subbed out of Saturday's match against Port Adelaide at Kardinia Park in the final term, with the 32-year-old unable to run out the game after pulling up sore.

The midfielder waved off medical assistance in the opening half after suffering a suspected knee injury, but another ailment late into the match was enough for the Cats to put their explosive ball-winner on ice.

Fox Footy's Sarah Jones told the broadcast Dangerfield was dealing with "tightening in the calf".

The Cats were able to bring young forward Gryan Miers into the game, having held a 27-point lead at the time of the change.

Dangerfield has already missed multiple matches this season through injury and load management, with a corked calf having forced him to the sidelines for Round 6 and 7.

Cats defender Zach Guthrie was also under the assessment of medical staff earlier in the match after copping a hit to his face.

The young backman was required to deal with a nosebleed in the opening half before eventually returning to the field after a stint on the sidelines.

Geelong ran out the match 35-point winners to secure their sixth win from the opening 10 rounds of the season.