Melbourne defender Oscar McDonald is set to depart the club during the off-season, reports SEN's Sam Edmund.

The 24-year old has fallen out of favour at the club - playing 19 games over the last two seasons.

McDonald is out-of-contract with the Demons and while contract talks were reportedly positive earlier this season, Melbourne have since cooled on him.

As McDonald is not eligible for free agency, he would need to be traded to another club to facilitate a move.

The backman has played 81 games for the Demons over six seasons, getting drafted with Pick 53 in the 2014 AFL Draft.

He isn't the only Demon linked with a move away from the club, with brother Tom McDonald and Braydon Preuss also drawing speculation.

Tom McDonald is likely to remain at Melbourne despite a significant drop in form over the last two seasons, who still has two years to run on his contract.

The Swans and Giants have both reportedly shown interest in Preuss, who also has two years left on a four-year deal he signed at the end of 2018.