GWS will be without ruckman Dawson Simpson for the remainder of the 2018 season, after he tore ligaments in his ankle.
Simpson has been ruled out for eight weeks, while the Giants are also yet to put a timeframe on Brett Deledio's injury, after he sustained another calf problem.
Toby Greene and Sam Taylor will both miss at least a fortnight after the pair suffered hamstring injuries during their 105-point win over Carlton on Sunday.
“Essentially he’s torn the ligaments on the inside of his ankle called the deltoid ligaments and they’re really tough and strong ligaments. They’re really tough to damage in isolation,” GWS' Head of Athletic Performance David Joyce told gwsgiants.com.au.
“Because of the way the foot has fallen he’s managed to fracture his ankle on the other side so on the lower part of the fibula he’s got a compression fracture there.
“The big fella is in remarkable spirits considering what he’s been through, but this will be a lengthy rehab, unfortunately.”
Deledio's injury could see him miss the rest of the season too, with Joyce suggesting the Giants would be ultra-conservative given the veteran's history of calf issues.
“Brett has injured his left calf, he’s had well documented issues with both calves in the past and unfortunately this just adds to that,” Joyce said.
“We will need to be pretty conservative with this injury given the history that we’re dealing with.”
However, despite losing four men to injury, the Giants could welcome four players back this weekend, as Tim Taranto, Dylan Shiel, Sam Reid and Ryan Griffen are all expected to train on Wednesday.
