Dynamic Western Bulldogs midfielder Bailey Smith will miss at least the next two games with a calf strain.

Smith was announced out at team selection on Thursday night and will miss the Dogs' blockbuster against the Power on Saturday, as well as at least their Round 6 match against Fremantle next Friday night at Optus Stadium, per AFL.com.au's Josh Gabelich.

Smith's exclusion from Luke Beveridge's side was one of four changes made on Thursday, as Robbie McComb (omitted), Alex Keath (concussion) and Hayden Crozier (back) will not suit up against the Power, replaced by Tim O'Brien, Taylor Duryea and Cody Weightman, with substitute Mitch Hannan retaining his spot after last week's clash with Richmond.

After facing the Dockers next week, the Bulldogs will have spent eight days away from home after making the trip to Perth for their Round 6 clash immediately following their Gather Round clash with Port Adelaide this weekend.

The Western Bulldogs' game against Port Adelaide on Saturday, April 15 (7:20 PM local time) will be the second game of an Adelaide Oval double-header, with Essendon and Melbourne set to do battle at the venue at 3:40 PM.