Brisbane are fearing the worst for two of its players following a night of "carnage" that led to one of the club's "greatest ever wins".

The Lions' plans for Sunday night's QClash were thrown into disarray during the warm-up when defender Brandon Starcevich reported a calf issue to the club's medical team, with the backman a late out for the Lions.

Without a carryover emergency on standby, Brisbane called on first-year forward Logan Morris to make his AFL debut as the tactical sub just hours after he playing in the Lions' VFL game against Gold Coast.

Morris' break wouldn't long as small forward Lincoln McCarthy went down with a concerning knee injury in the opening term.

The Lions then lost defender Noah Answerth to a failed concussion test, before defender Darcy Gardiner's night was brought to a close in the second quarter after hurting his knee in a marking contest.

Both Gardiner and McCarthy are expected to be dealt with season-ending setbacks when the pair undergo scans on Tuesday.

"More than likely they are (ACL injuries), which is really unfortunate," Brisbane coach Chris Fagan said post-game.

"When I saw them, they just had that look about them. There's a certain look about ACL injuries. The doctors pretty much think that'll be the case.

"There'll be scans on Tuesday and that'll probably just confirm what is already known."

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The unprecedented circumstances of the Lions' 34-point victory left Fagan immensely proud of his players, who were left with just two on the interchange for a majority of the match.

Fagan went as far as to say the win was "the most amazing and courageous" he'd been a part of in football, lauding his team's fight to stave off their state rivals.

"I've been involved in footy a long time and I've never seen the carnage that happened," Fagan added.

"I think it's the most amazing and courageous win I've ever seen by any group of players I've had anything to do with. I'm just so proud of them.

"The heart that they showed to play in that manner... to withhold a Gold Coast team that probably understood that we might've been out on our feet, it just shows a great deal of character.

"It'll go down at our club as one of our greatest-ever wins. I don't think you can look at it any other way."

The Lions could regain Callum Ah Chee (hamstring) from injury for next Sunday's trip to South Australia to face Adelaide.

The extent of Starcevich's setback is not yet known, while Answerth will enter concussion protocols and miss the Round 9 encounter.

The win for the Lions sees the Queensland club sit two wins from the top eight with a record of 3-5.