While Pickett faces a nervous wait ahead of the Match Review Officer's findings from Saturday's action, Goodwin could welcome the returns of Bayley Fritsch, Steven May, Jack Viney and Christian Salem for the trip to Queensland.
Speaking after his side's Round 1 win, Goodwin said he expects the quartet to be right in the mix for selection.
"I'm pretty confident all four will be available," Goodwin said
"May, Salem, Fritsch and Viney are all looking promising based on their training today."
McVee will be a strong chance to retain his place in the side despite Salem's potential return, while Laurie will find some competition from Fritsch.
The former first-round pick could be retained in Goodwin's 22-man side for the trip north if Pickett is suspended for the match.
"It gives us a few headaches that's for sure, because we've got a lot of guys pushing," Goodwin said of the selection dilemma.
"Both guys had impact in the game in a variety of ways and that puts pressure, but it's a healthy pressure to have."
Pickett will learn his fate on Sunday evening and is potentially facing multiple weeks on the sidelines for his bump on Bulldog Bailey Smith.
Melbourne will face Brisbane at the Gabba on Friday night, with the match to commence at 7:50pm (AEDT).