Perth's three-day lockdown is set to have large ramifications on the next few weeks for the AFL, with as many as seven clubs already impacted.
On Friday the Western Australian Government confirmed that the Perth and Peel districts would enter a snap lockdown after a resurgence of community transmitted COVID-19 cases.
The lockdown will mean Saturday night's fixture between Fremantle and North Melbourne at Optus Stadium will take place behind closed doors.
The AFL and the Kangaroos are currently working with the Victorian government to allow North Melbourne to return home after their clash against the Dockers and avoid a 14-day quarantine.
The league will also be in discussions with the Tasmanian Government as the Kangaroos are scheduled to face Melbourne at Blundstone Arena in eight days time.
There is a likely outcome where that game is moved to Marvel Stadium depending on whether or not the Kangaroos are granted an exemption to enter the island state without being required to quarantine.
The West Coast Eagles have already been given the all-clear to face Geelong on Saturday afternoon, with any patrons from red-zone areas of Western Australia told not attend the match at Kardinia Park.
It’s back: notice on the big screen at GMHBA warning anybody from hot spots in WA to go home. Could be another weird afternoon down here
— Josh Barnes (@Josh__Barnes) April 24, 2021
The Eagles faced Collingwood in Round 5 last Thursday, with that encounter now placing Magpies players in isolation and away from training on the eve of their ANZAC Day clash against Essendon.
Collingwood's training was cancelled as players await results of their COVID-19 tests, but Sunday's clash is set to go ahead as planned.
Magpies midfielder Brayden Sier will not feature in Collingwood's VFL side this weekend after he returned from Perth and was listed to face Essendon's reserves at Victoria Park.
Carlton have also been brought into the latest COVID-19 whirlwind, with incoming consultancy coach John Worsfold told to isolate until he receives a negative test.
Carlton the latest team to be impacted by Perth Covid chaos.
John Worsfold was meant to be in the Blues coaches box for first time today but has been forced to isolate and get tested after flying in on Thursday. Won’t get results back in time #AFLBluesLions @7NewsMelbourne @7AFL
— Andrew McCormack (@_AMcCormack7) April 24, 2021
Worsfold arrived in Victoria from Perth ahead of the Blues' clash with Brisbane on Saturday afternoon at Marvel Stadium.