Collingwood have confirmed their second debutant of the 2023 season, with first-year defender Jakob Ryan to face Brisbane on Friday night.

Taken with the 28th pick in last year's National Draft out of Glenelg, South Australia as the Magpies' second selection of the count, Ryan has since impressed his coaches with his immediate impact at VFL level.

Ryan has averaged 19.6 disposals and five marks in the VFL this year from 14 matches, having missed a handful of games in his debut season due to a neck/shoulder injury.

The 189cm teenager offers run and good ball use from the defensive 50 and can move further up the ground to have an impact.

Ryan joins forward Harvey Harrison in making his Collingwood debut in 2023.

Collingwood confirmed Ryan's inclusion into the starting side on Wednesday, with coach Craig McRae set to make at least three changes following captain Darcy Moore's hamstring injury.

"He's been in great form for a number of weeks now," McRae told reporters of Ryabn's inclusion.

"It's exciting to give someone an opportunity this time of the year. He gets it through reward and playing above the level in the VFL."

Midfielder Jordan De Goey (glute) and forward Bobby Hill (hamstring awareness) will also make way due to injury alongside Moore.

Half-back John Noble (ankle) and wingman Steele Sidebottom (foot) have been cleared to play, with the latter to make his return after missing the Round 22 win over Geelong.

"Steele will play, he got through training and looks alright," McRae said.

"We'll have a few out. Obviously Darcy Moore won't play. Jordy and Bobby Hill won't play as well. John will play.

"If it was a grand final we'd be pushing for all of them to play, but we're not in that situation right now. We'll look after those guys and make sure they're alright."

The Magpies will confirm their squad on Thursday night at 6:20pm (AEST).

Collingwood and Brisbane will clash at Marvel Stadium on Friday night at 7:50pm, where a win for the Magpies will see them secure the minor premiership.