A pair of fresh injuries look to have hit Carlton's squad ahead of their Good Friday clash with North Melbourne, while a luckless young Eagle has been hit with another setback.

In the Blues' selection announcement on Thursday evening, the club revealed forward pair David Cuningham (calf) and Jesse Motlop (hamstring) wouldn't be available to play against the Roos at Marvel Stadium.

Motlop was recently working his way back from a toe injury sustained late into the pre-season and was cleared to be available for selection as recently as Tuesday.

Cuningham, who featured in Carlton's Round 1 win over Richmond, joined Motlop in being ruled out of this week's encounter following the Blues' main session on Wednesday.

The club did not disclose the extent of the duo's injuries.

Cuningham's absence saw the Blues half-forward join Brodie Kemp and Lewis Young in being withdrawn for Round 3, with reigning best and fairest winner Jacob Weitering joined by recruit Elijah Hollands and Caleb Marchabnk as the inclusions for Michael Voss' side.

Carlton WON BY 56 POINTS
Marvel Stadium

Meanwhile, uncapped West Coast defender Coby Burgiel is facing several weeks on the sidelines after needing his appendix removed.

The teenager underwent surgery on Wednesday and will again join the Eagles' casualty ward, having recently returned from a hamstring injury.

Burgiel suffered repeated hamstring setbacks last year to play just three WAFL games for West Coast's reserves, making for a frustrating first season for the Gippsland product.

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The dashing defender joins the likes of Oscar Allen (knee), Elijah Hewett (foot), Liam Ryan (hamstring), Archer Reid (knee), Matthew Flynn (knee), Dom Sheed (foot) and Jai Culley on the Eagles' injury list.