Tom Bugg, Pat McKenna, Mitch King and Lochie Filipovic have all joined Cam Pedersen in being delisted by the Demons on Tuesday.
Pedersen announced his own delisting on social media on Tuesday afternoon, before the club confirmed the remaining four players who would not be offered a contract for the 2019 season.
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The tall ruck-forward played 64 of his 80 AFL games with Melbourne, while Bugg played 31 of his 96 at the Dees.
The remaining trio did not make their AFL debuts at Melbourne.