According to Fox Sports' Tom Morris, Demons defender Joel Smith has sustained a hamstring injury at training in the build-up to the match, opening up at least one hole to be plugged for their must-win match in Perth.
It is understood that veteran defender Michael Hibberd is set for a call-up to replace Smith for his second game since Round 19, with coach Simon Goodwin reportedly not opting for speedster Jayden Hunt.
Hunt has battled an ankle injury for the past month, with the Demons flagging earlier this week the 26-year-old will be in the running for selection.
“It will be a matter of time for Hunty. He’ll need to train really well on Tuesday and we’ll have match committee after that session to make sure everyone’s pulled up ok and we get the tick off from the conditioning and medical staff," Demons football boss Alan Richardson told SEN.
“Hunty will definitely be in the mix, we’ll just have to wait and see on that one.”
Smith's setback will be a heartbreaking blow for the backman, who returned to Goodwin's side in Round 22 for his first appearance at AFL level since last year.
The forced change is likely to be the Demons' only moving of the magnets since their 33-point qualifying final win over Brisbane.
Hunt, along with veteran Nathan Jones and young gun James Jordon, will be looking to break into the Demons' side ahead of Thursday selection, with a win against the Cats giving Melbourne a chance of breaking their 57-year premiership drought.
The Demons will host Geelong at Optus Stadium on Friday night, with the match commencing at 7:50pm AEST.