Thursday saw the release of the 2022 AFL fixture and had fans of all creeds clamoring to see where and when their sides are set to do battle.

While there are plenty of marquee matches that all AFL fans will be excited about, grand final replays, ANZAC Day, Dreamtime and Queens Birthday are just a handful of the big games already signposting the upcoming season.

Given players and coaches have changed clubs, milestones and early absences have all resulted in some intriguing matches, this means that there are some unexpected games that could be some of the most can't miss football of the season.

Ahead of the Christmas break, we have had a look at some of the big matchups and moments that you will want to keep an eye on in 2022.

3. Dangerfield vs North Melbourne - Round 16

MELBOURNE, AUSTRALIA - JUNE 29: Patrick Dangerfield of the Cats smiles at Jordan Cunico of the Cats during the 2018 AFL round 15 match between the Western Bulldogs and the Geelong Cats at Etihad Stadium on June 29, 2018 in Melbourne, Australia. (Photo by Adam Trafford/AFL Media/Getty Images)

Dangerfield has been a dominating force in the league for most of his 285 games and has consistently been one of the league's best, and most prominent, players.

This season he will likely play game 300, which is currently poised to be against North Melbourne in Round 16.

This game at the GMHBA Stadium would be another sold-out milestone match. Still, unlike Selwood's 350th however, this game is unlikely to be moved away from Geelong.

This could be an ideal matchup for the Cats, who have historically underperformed in milestone matches. Based on expectations and 2021 results, this should be one of the easier matches on the fixture for Geelong.

Geelong faces Adelaide in Round 11, which could have been the perfect opponent for Danger's 300th, but what would have been a bittersweet moment for Adelaide fans, is virtually impossible for this matchup.

What could happen though is both Selwood and Dangerfield having their milestone matches in the same match. If Danger misses one more game than Selwood this season then, they would both be on track to reach those games the same week.