Petrevski-Seton, in his second season with the Eagles, has missed the last five games due to a bruised cork, whilst concussion put Edwards in the league's mandatory 12-day concussion protocols after sustaining a head knock against Essendon in Round 11.
Speaking to the club's website, West Coast Head of Health Mark Finucane said all four players will need to get through the main training session to be available for selection.
"Luke (Shuey), Luke (Edwards) and Samo (Petrevski-Seton) just have to get through main training this week to be available for the weekend," Finucane said.
"All have progressed through their respective rehabilitation programs.
"Jack's been an absolute pro in looking after his arm so he's actually pushing to play this weekend. He's got to get through training later in the week and then he might be a chance to play against Adelaide.
The Eagles will be without former skipper Shannon Hurn for 2-3 weeks (hamstring), while Connor West (knee), young ruckman Callum Jamieson (hip), Elijah Hewett (concussion), and Tom Barrass (hip), who will miss a second straight game after being a late withdrawal from the Collingwood clash, will also miss.
Barrass will be ready to return after the club's Round 14 bye.
"Unfortunately, 'TB' felt a grab in his hip in Captain's Run. With the timing just prior to the (last) weekend's game it's going to be too tight for this weekend, so we're looking at TB returning after the bye," Finucane said.
Meanwhile, ruckman Nic Naitanui's season is over after visiting a specialist to assess an ongoing Achilles issue which has seen him not feature this season.
Speaking to media on Wednesday, coach Adam Simpson confirmed the news, reamioning hopeful the veteran could make a full recover for 2024.
"He was going okay. Then he stagnated," Simpson told reporters.
"He had another scan, it wasn't good. So he will have surgery and it will be a long stint out.
"The season is out of the question, but he can make a full recovery. I have been told he is unavailable for the season."
Naitanui's absence will only strengthen the chances of first-year ruckman Harry Barnett making his debut this year, with Jamieson also unavailable to leave Bailey Williams as the club's only experienced ruckman.
Simpson said Barnett will be named in the squad for the trip to SA, with the teenager in the mix for selection.
"He is in the squad. He is 18," Simpson said of the South Australian.
:He will take a while to mature to the level he needs to. He is in the mix."
Liam Duggan, who has been managing an illness this week, won't be available for the trip to the City of Churches after deciding not to appeal his one-match ban for a dangerous tackle on Collingwood's Taylor Adams
West Coast are dealing with a lengthy injury list which includes Liam Ryan (hamstring), Isiah Winder (knee), Jamaine Jones (ankle), Jai Culley (knee), Jamie Cripps (ankle), Tom Cole (ankle) and Coby Burgiel (hamstring).