Assistant coaches Corey Enright and Brendon Lade are currently away from the club, while new Head of Performance and Conditioning Nick Walsh and high-performance staffer Marcus Krygger have also been hit by the virus.
Lade will be absent from gameday duties and will take on a role away from the coaches box - similar to what Ratten experienced in Round 5 when he was in health and safety protocols - when the Saints take on Melbourne at the MCG on Sunday.
Enright is anticipated to be available for the Round 8 bout, however.
"I was hoping you wouldn't ask me that," Ratten chuckled at his media appearance at Moorabbin on Thursday morning.
"Corey Enright will be available for gameday, [when] he comes out... 'Ladey' will do exactly what I did.
"At times we're gonna have challenges... It's life at the moment."
As far as on-field personnel, the Saints are currently in the clear after having been forced to call on reinforcements after a trio was sidelined under similar circumstances in recent weeks.
Spotted: Mason Wood and Marcus Windhager in what looks to be the 'B' team in Match Sim at Moorabbin.
Jack Billings and Zak Jones also in white.
— Nick Splitter (@nicksplitter) May 5, 2022