Mature-age Essendon draftee Alec Waterman will reportedly make his AFL debut with the club this weekend.

AFL Media's Callum Twomey reports that the 24-year old will get his opportunity in Saturday's clash against St Kilda.

"Alec Waterman set to make his AFL debut with Essendon this week. Having been delisted by West Coast, where he had an illness-hit stint, he made his way back to the top level via the WAFL and then the SSP rookie rule, so promises to be a feel-good story. @AFLcomau," Twomey tweeted.

Waterman signed with the Bombers during the pre-season supplemental selection period after a dazzling four-goal performance in a practice match against Carlton.

The Bombers have suffered several injury blows in the fallout from Round 2 - with Dam Draper (ankle), Jye Caldwell (hamstring) and Dylan Shiel (knee) all set to be sidelined for an extended period of time.

But crisis creates opportunity as Waterman gets his second chance at AFL level, having played eight games for West Coast from 2015-2016 where injuries held him back and led to his delisting.