Geelong have made two big changes to their side ahead of their clash with Hawthorn at the MCG on Saturday afternoon.

Defender Andrew Mackie and midfielder Scott Selwood have both been withdrawn from the match, and will be replaced by youngsters Sam Simpson and Zach Guthrie.

Mackie will miss his first match of 2017 after being withdrawn due to a wrist injury, while Selwood will miss his third game in a row with hamstring tightness.

Simpson will come in for just his second career game after debuting against the Giants two weeks ago, while it will be Guthrie's third match after making his debut in the same game.

Hawthorn will remain unchanged.