Collingwood swingman Ben Reid's season could be over after injuring his calf in the VFL today.

The 29-year old sustained the injury during the third quarter of the Pies' thrilling two-point win over Port Melbourne at Port Oval and missed the rest of the game.

Reid has managed just six AFL games this season after struggling through injuries, returning for his first hitout today in over two months.

Should the premiership defender miss the rest of the season, he would join a host of Magpies whose campaigns are over, including Matthew Scharenberg, Lynden Dunn, Daniel Wells, Tim Broomhead and potentially Jamie Elliott and Darcy Moore.

"I think he just felt his calf a little bit when he went for a contest," Collingwood VFL coach Jared Rivers told Channel Seven.

"It was really unlucky for Ben. He has worked so hard to get himself into a position to play footy (again).

"Today he probably just hurt himself a little bit so we will assess during the week and see where he is at. It is really disappointing for him."

In other injury news, Demons veteran Bernie Vince is also set for a stint on the sidelines after dislocating his shoulder while playing for Casey in the VFL today.