Clarke has played 110 AFL games, with nine of those coming for Essendon this season.
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Long wore the red and black during five AFL games, while Jok made his one and only appearance for the club in round 23.
Mynott was on the list for two years, but didn’t make his senior debut.
“On behalf of the club, I would like to extend our thanks and appreciation to Zac, Trent, Jake and Tuth for their contribution to the red and black,” Essendon’s general manager of football Dan Richardson told essendonfc.com.au.
“It is always a difficult time of year saying goodbye to quality people, so we wish all four gentlemen the best for their future endeavours.”