The GWS Giants will have Josh Kelly, Lachie Whitfield, Harry Perryman and Jesse Hogan in the mix for selection ahead of their Round 20 clash with New South Wales rivals Sydney.
Kelly, who missed last Sunday's loss to Carlton through concussion, will undergo further testing when he exits league protocols following a head knock sustained the week prior against Brisbane.
Whitfield has missed the past fortnight with a hip issue, while Hogan was managed ahead of Round 19 due to an increase in workload this season.
Perryman has not featured at senior level since Round 13 after sustaining four broken ribs against North Melbourne and will be in line to make his return this weekend at the SCG.
An ankle injury will see ruckman Matt Flynn ruled out of the match, while defender Connor Idun has been ruled out for the remainder of the year due to a foot injury.
2022 debutant Ryan Angwin will also be sidelined for the finals rounds of the year due to a leg injury sustained in his first AFL game in Round 14.
Idun and Angwin join Jack Buckley and Brent Daniels in being placed on ice for the remainder of the 2022 campaign.
Young pair Conor Stone and Finn Callaghan may be available in the coming weeks as their recovery from respective hamstring and foot issues comes to a conclusion.
Following surgery for testicular cancer, small forward Bobby Hill is back into light training drills as he remains on an indefinite timeframe for a return.
The Giants will face the Swans at the SCG on Saturday, with the match to commence at 2:10pm (AEST).