Star Bombers midfielder Darcy Parish is a test for this weekend's clash with West Coast in Perth, while back-flanker Andy McGrath and key forward James Stewart are each set to miss multiple weeks due to respective injuries.
Bombers head of high-performance Sean Murphy detailed the process behind assessing Parish's availability this week.
"He'll be a test for this weekend," Murphy told Essendon's website.
"All things considered, he's just got to keep progressing. It was a very decent calf cork that he copped and there's a fair bit of blood in and around that area.
"We'll just get him going this week and by main training on Wednesday, he'll get out there and do a bit and we'll assess what his availability will be like for this weekend."
Meanwhile, McGrath suffered an adductor injury during the win over the Saints and is now poised to spend a stint on the sidelines.
"Andy was really unfortunate to have that adductor strain," Murphy said.
"It came on just into the third quarter. He was able to play out the game, but unfortunately, it means he'll miss a couple of weeks now."
"'Stuz' was really unfortunate to get a plantar fascia injury," Murphy said.
"He'll probably miss a couple of weeks and we'll see how that settles down over that time."
Promising key backman Zach Reid is another member of the Dons' casualty ward and is also a test for this weekend as he recovers from a rolled ankle.