The West Coast Eagles are in crisis mode just 48 hours out from their Round 2 clash with North Melbourne, with as many as 12 players expected to be ruled out of the clash.

The crisis is so bad that the club have delayed flying to Melbourne by a day to work out who won't be available for the game, with senior coach Adam Simpson revealing on Friday 12 players from their Round 1 defeat won't be available for this weekend.

Star forward Josh Kennedy was ruled out of the game on Thursday, along with Tom Barrass, Jack Redden, Zac Langdon and Isiah Winder, while Josh Rotham joined the quintet by testing positive on Friday.

That number could be higher, with a dozen players set to miss either through injury or health and safety protocols.

Simpson revealed the club will only have 17-18 AFL-listed players at his disposal given the influx in case numbers and close contacts.

The Eagles have been able to welcome back Liam Ryan and Tim Kelly from the AFL's health and safety protocols, with the star pair having missed their side's opening round loss to the Gold Coast.

Forward Jack Darling, defender Alex Witherden and captain Luke Shuey were confirmed as inclusions for Sunday's match at Marvel Stadium when teams were announced on Thursday night.

Simpson confirmed debutants for their Round 2 bout with the Kangaroos, however the coach was reluctant to name any first gamers given the unprecedented circumstances.

The Eagles will heavily rely on top-up players for this weekend, with the club understood to be contacting WAFL clubs and players listed on their COVID contingency plan.

WEST COAST'S TOP-UP LIST:

WCE Ryan Ambrose West Coast WAFL
WCE Joey Deegan West Coast WAFL
WCE Zane Sumich West Coast WAFL
WCE Logan Young West Coast WAFL
WCE Damon Greaves East Perth
WCE Angus Schumacher East Perth
WCE Brayden Ainsworth Perth
WCE Corey Byrne Perth
WCE Angus Dewar Subiaco
WCE Stefan Giro Subiaco
WCE Sam Fisher Swan Districts
WCE Tobe Watson Swan Districts
WCE Steven Miller Claremont
WCE Aaron Black West Perth
WCE Tom Blechynden South Fremantle
WCE Jackson Ramsay East Perth
WCE Declan Mountford Claremont
WCE Luke Meadows West Perth
WCE Jake Florenca South Fremantle
WCE Chad Pearson South Fremantle