West Coast defender Brad Sheppard will now face a race against time to be fit for the Eagles' home preliminary final against either Hawthorn or Melbourne in 14 days' time.

Sheppard left the field in the first quarter after suffering a hamstring injury, and did not return for the remainder of the contest.

The 27-year-old will now face a nervous wait before scans reveal the extent of his injury.

Eagles coach Adam Simpson expects his star defender to miss some time, although he hopes it's not as bad as it looked.

"Unfortunately, 'Shep' might miss a game, he might miss a couple," Simpson said post-game.

"The look in his eye (post-match), he was pretty disappointed personally that he couldn't contribute and that he might potentially miss another game coming up."

Sheppard has played 95 games straight for West Coast, dating back to Round 1 of the 2015 season.