The Dons' reinvigorated efforts to draw Setterfield from Princes Park have arisen in the wake of their fruitless chase of Suns utility Jack Bowes.
As reported by News Corp, the Bombers have narrowed their sights on the 24-year-old in the hopes that a late selection will be enough to satisfy the Blues at the trade table.
Previous reports from September suggested that Essendon held a desire to see Setterfield don the sash in 2023 in an effort to add size to their stoppage team.
Standing at 192cms and tipping the scales at 99kgs, the former first-round draftee has the request size to influence inside contests, despite failing to see much action at the coalface across the brunt of his time as a Blue.
At present, Essendon is currently armed with picks 4, 22, 42, 62 and 80 in an effort to get a deal done with their long-term arch-rivals.
Since crossing from the Giants ahead of the 2019 season, Setterfield has featured in a Navy Blue guernsey on 34 occasions.