Carlton midfielder Natalie Plane has been ruled out for the remainder of the AFL Women's season due to a high grade ankle sprain.

The 20-year-old sustained the injury during the Blues' win over Collingwood at Ikon Park on Friday night.

Tahni Nestor has signed with the club for the rest of the season as an injury replacement.

"While it is very disappointing to lose Natalie with a season-ending injury, we now welcome Tahni as a top-up player," Carlton coach Damien Keeping told the club's website..

"Tahni has a fierce thirst for the contest and is a neat kick. Tahni's openness to learning will ensure she fits with the culture of our playing group."