Culley, a 2022 mid-season draftee, went down early against Richmond in Round 8 with scans subsequently revealing an ACL tear on his right knee.
With the 20-year-old midfielder to be moved to the inactive list, senior coach Adam Simpson has revealed the Eagles' plans to restock through the Mid-Season Draft.
"We're meeting on that this week," Simpson told 7NEWS Perth.
"With a spot on the list available, more likely than not, we will look at doing that."
Gippsland Power forward Ryan Maric is one on the radar of West Coast, with the 19-year-old proving to be a dangerous goalkicker in the Coates Talent League this season.
Claremont key forward Jack Buller is another attractive option for the Eagles, with the 199cm Western Australian averaging 18 disposals and two goals a game at WAFL level.
Before his season-ending injury, Culley was finding form as a midfielder-forward, and delighted with a four-goal Round 6 showing against Port Adelaide to claim a Rising Star nominee.
Simpson has lamented the poor luck of his first-year player.
"Tragic news really," he said of Culley's ACL rupture.
"Really disappointing for him, and he hasn't even been here 12 months... he'll miss the rest of the year.
"He's pretty resilient, he got here the hard way, and I'm sure he'll get back the hard way as well."
The Eagles have been ravaged by injury this season, with Culley's unavailability complicating their list situation further.