GWS veteran Adam Kennedy's season is over after scans revealed a torn ACL from Saturday's loss to Brisbane.
Kennedy suffered the injury following a collision with Brisbane's Keidean Coleman that resulted in the defender landing awkwardly on his knee.
The club confirmed on Sunday that Kennedy will miss the remainder of the season due to the knee injury.
“It's shattering news for Adam and the club but we'll wrap our arms around ‘Kenners' and give him all the support he needs,” GWS football boss Jason McCartney said in a club statement.
“He's a much loved member of our footy club and we know he'll attack this setback with his trademark hard work and diligence.”
Fellow defender Sam Taylor will miss close to 10 weeks with a grade three hamstring injury sustained in the third term of the defeat to Brisbane.
McCartney said it was a disappointing outcome for the All-Australian defender.
“Unfortunately Sam will miss around 10 weeks with this hamstring injury,” McCartney said.
“It's frustrating for Sam, who has been in exceptional form, but we look forward to welcoming him back after our mid-season bye.”
The Giants have also confirmed that young pair Leek Aleer (ankle) and Cooper Hamilton (navicular) will miss the coming rounds, while forward Dan Lloyd remains a test for Round 7 with a calf issue.
GWS will face arch-rivals Sydney at the SCG next Saturday.