Young Port Adelaide pair Jase Burgoyne and Mitch Georgiades have both required operations to assist knee and ankle injuries respectively.
After landing awkwardly during a training session at the club's pre-season camp this week, Burgoyne required an assessment on his right knee before the club opted for surgery.
Burgoyne underwent an arthroscopy on Friday to have the lateral meniscus trimmed, meaning the teenager will be sidelined for the coming weeks.
It is expected that Burgoyne will be back running next month.
Meanwhile, Georgiades gained further treatment for his syndesmosis setback, which required post-season surgery earlier this year.
After suffering irritation, Georgiades was required to undergo a procedure to remove syndesmosis buttons from his ankle to aid the pain.
It is expected that Georgiades will return to running in the new year.
All Port Adelaide players have finalized their pre-season plans for 2022, with training to resume on January 9.