Collingwood will be without veteran wingman Steele Sidebottom for Friday's clash with Geelong due to a foot issue.

The Magpies are already forced into making at least one change for this weekend's clash against the reigning premiers, with star midfielder Nick Daicos set to miss up to six weeks with a hairline fracture in his knee.

Defender Nathan Murphy was also placed in doubt to face Geelong due to an ankle injury that was also sustained in last Saturday's loss to Hawthorn, however the Magpies backman remains in the mix for selection for Round 22.

While Collingwood Craig McRae is expecting Murphy to be fit, the second-year senior coach has revealed Sidebottom won't play this week as he deals with a foot concern.

On Wednesday McRae confirmed Sidebottom won't be named, doubling the Magpies' midfield concerns following Diacos' setback.

"Steele won't play," the Magpies coach said.

"He's got a sore foot. If we had an extra couple of days (of recovery) he'd be available.

"He's been carrying it for a couple of years. Every now and then it gets a bit grumbly, and right now it's a bit grumbly.

"He just needs a bit of extra time to recover. Hopefully he's right next week."

Daicos' older brother Josh looms as the best-suited teammate to take on the young star's role under McRae for the coming rounds, however Sidebottom's absence only raises the reliance on Josh Daicos' role as the opposing wingman in McRae's system.

Collingwood's selection committee is likely to look toward fringe midfielders Trent Bianco, Josh Carmichael or Finlay Macrae, with the latter two needing to prove their fitness this week after battling hip and thumb injuries respectively.

Dashing defender Oleg Markov is primed for a starting role to help add speed and run in the absence of Nick Daicos, while draftee Ed Allan and defender Trey Ruscoe could also be in consideration.

Forward pair Jack Ginnivan and Will Hoskin-Elliott will also be in the mix after serving as emergencies in the Hawks loss.

McRae labelled Murphy's potential availability as "remarkable" after his home and away campaign intially looked over due to a low-grade syndesmosis diagnosis.

The Magpies rested fringe defender Billy Frampton from last Sunday's VFL hitout due to Murphy's injury, with both backmen now in the mix to face the Cats.

"The doctors said 2-3 weeks, it ended up being 2-3 days. It's quite remarkable," McRae said.

"He got through training, it'll be whether he pulls up well. We'll see how that goes, it'll be hard not to pick him if he pulls up well.

MELBOURNE, AUSTRALIA - JUNE 13: Nathan Murphy of the Magpies marks the ball during the round 13 AFL match between the Collingwood Magpies and the Melbourne Demons at Melbourne Cricket Ground on June 13, 2022 in Melbourne, Australia. (Photo by Darrian Traynor/Getty Images)

"There might be room for both (Murphy and Frampton), we'll just have to see what team they pick and we'll work through that this afternoon.

The Magpies will announce their squad on Thursday evening, while the club is yet to confirm the extent of Sidebottom's setback.

Collingwood will host Geelong at the MCG on Friday night at 7:50pm (AEST).