A confirmed positive COVID-19 case has forced Collingwood players and staff into mandatory testing and isolation.

7 News first reported that the club was notified of a possible COVID-19 case on Monday, before confirming the positive test result on Tuesday morning.

The Holden Centre will be closed for a deep clean as staff are moved to work remotely during their quarantine periods.

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The disruption comes just one week into Craig MacRae's tenure as new senior coach, with the club still remaining hopeful his appointment will bring new results.

The Magpies finished 17th on the ladder this season, recording just six wins.

Last weekend, MacRae told The Age he hopes to ignite a change in fortune through more work on leadership and contested football.

“There is a bit of work to do in our leadership group. I’ve known that for a little while. And I say that with all respect, but I think we’ve got to get better in all areas and I think leadership is a starting point", he said.

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This week's COVID-19 scare is a timely reminder that virus is still a threat, as Magpies players - now freed from any footballing duties - begin to take the opportunity to get vaccinated.

Although no official ruling has been made, a decision on whether vaccines will be made mandatory for players is looming.