Sydney coach Dean Cox has confirmed that Isaac Heeney won't face Hawthorn on Thursday night as he was unable to overcome a minor hamstring injury.
The five-day turnaround was too short for Heeney to recover, with Cox saying they're more concerned with risking the star.
"He came close," Cox said.
"The five-day break didn't help, but having said that, it's really important with the player he is to manage him first."
Errol Gulden is also another forced withdrawal for the Swans, with the classy left-footer sidelined for up to four months with a shoulder injury.
Cox is considering bringing in like-for-like players, with Caiden Cleary and Corey Warner up for consideration.
"We'll look at a different mix through the midfield," Cox added.
"(Heeney and Gulden) have been stable parts of our playing group for a long period of time. So, we'll do some different things with some personnel that we put through there.
"We get a chance for a couple of our younger players. Caiden Cleary, Corey Warner, and the like, to come into the footy team, because they've been in really good form over the summer and in the pre-season."
Hawthorn's two-ruck selection in Lloyd Meek and Ned Reeves is also making Cox consider bringing in Hayden McLean or Peter Ladhams to help Brodie Grundy. The pair were emergencies last week against Brisbane.
Logan McDonald and Joel Amartey shared the ruck loads in Round 1 alongside Grundy.
The Swans coach alluded to the Hawks' tall defensive stocks, and adding height in the front half is another option.
"That still might happen," Cox said.
"The impact (Hawthorn's rucks had was immense). So, the ability to support Brodie is really important.
"We need to make sure that, yes they do have talls behind the ball that are really good at intercepting, as well as the two rucks, so that's something we've spoken about all week."
