Giants veteran Brett Deledio's season could be over after injuring his calf against the Blues during their clash at Etihad Stadium.

He is not the only sore Giant, with star forward Toby Greene (hamstring tightness), defender Sam Taylor (hamstring) and ruckman Dawson Simpson (ankle) also facing health concerns.

Deledio and Taylor's injuries appear to be the most serious, with both players being put on ice. It is a serious concern for Deledio, who has struggled to get on the park for much of his time as a Giant due to his dodgy calf.

It also leaves GWS without any players to interchange in the fourth quarter.