St Kilda and Richmond have confirmed their sides to open the 2022 AFLW season.

The two Victorian clubs will begin the new campaign at Skybus Stadium in Frankston on Friday night, with new faces and key omissions headlining the respective lineups.

Tigers recruit and former Saints ruck Poppy Kelly will take to the field against her old club, while draftee Stella Reid and recent squad inclusion Bethany Lynch are also set to make their debuts in yellow and black.

Jess Hosking will also be welcomed into Ryan Ferguson's side, reuniting with sister Sarah as part of the Tigers' spine.

The Saints will be without trio Kate Shierlaw, Nicola Xenos and Molly McDonald due to the league's health and safety protocols, opening up opportunities for fresh faces.

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Lucy Burke, Alana Woodward and Leah Cutting will all make their St Kilda debuts, while Olivia Vesely returns from a season on the sidelines.

Friday's match is set to commence at 7:15pm AEDT.

ST KILDA

B: T.Lucas-Rodd 18 R.Ott 20
HB: B.Jakobsson 8 J.Van Dyk 36 H.Priest 14
C: A.Woodward 4 T.White 29 C.Phillips 35
HF: D.Guttridge 5 I.Shannon 11 K.McCarthy 9
F: C.Greiser 17 J.Vogt 10
Foll: R.Watt 7 O.Vesely 23 R.Dillon 25
I/C: J.Matin 19 L.Burke 30 A.Burke 3 R.Saulitis 13 L.Cutting 26

Emerg: E.Friend 16 T.Meyer 34

RICHMOND

B: R.Miller 15 H.Cordner 23
HB: S.D'Arcy 12 J.Hosking 11 K.Dempsey 19
C: T.Lavey 37 S.Hosking 7 M.Shevlin 35
HF: M.Brancatisano 5 G.Seymour 28 T.Stahl 24
F: K.Brennan 3 C.Wakefield 8
Foll: P.Kelly 14 M.Kiely 31 M.Conti 4
I/C: B.Lynch 32 E.Yassir 27 C.Bernardi 6 H.Burchell 9 S.Reid 25

Emerg: K.Jacques 10 M.Macdonald 38