Essendon are set for a big boost for their clash against Melbourne on Sunday as they likely welcome back key pair Orazio Fantasia and Conor McKenna.

The duo missed last week's win over Sydney as the Bombers now look to go 3-0 for the first time since 2013. 

McKenna wasn't even in the selection conversation as he had to self isolate after returning from Ireland, while Fantasia missed the match because of a quad injury. 

"He is going to be very close," Worsfold told reporters about Fantasia chances. 

"Friday is our main training and that's where he's going to have to get through and prove to us that he's available for selection, but it all appears to be tracking pretty well.

"We expect him to do full training and after that we'll work out whether he's available."

McKenna, who went home to Ireland during the AFL shutdown period, hindered his chances to run out last week given the timing around his quarantine. 

"He felt like he was ready to play, and he looks ready to play, but taking (his quarantine) into account, putting him into an AFL game would've been pretty high risk," Worsfold said.

"He'd only been out of quarantine and in training for two weeks and we needed every minute of the four weeks training together once we were back to get the squad prepared to play.

"The extra week we've used to get a good hit-out into him and we feel like he's a lot better prepared now."