Sydney, Collingwood and Hawthorn are also understood to be heavily impacted by COVID just days out from their respective Round 1 fixtures.
The Magpies have endured a spike in COVID cases and players being required to isolate across both their men's and women's systems, with their AFLW side likely to have their qualifying final against Brisbane postponed from this Saturday.
Collingwood midfielder Will Hoskin-Elliott and coaching pair Brendon Bolton and Josh Fraser are understood to be placed in health and safety protocols and will be unavailable for this Friday's clash with St Kilda at Marvel Stadium.
The Hawks, who are fixtures to face North Melbourne at the MCG on Sunday, are set to be without a handful of senior players due to similar reasons, according toย The Age.
Ben McEvoy and Luke Breust are set to be unavailable for selection, as they come up against fellow anticipated cellar-dwellers in the Kangaroos.
The Swans are the latest team to join the list of clubs facing the likelihood of losing key personnel for this weekend, with several players expected to miss their Round 1 bout with cross-town rivals Greater Western Sydney at Accor Stadium on Saturday.
The club has confirmed newly-appointed co-captain Callum Mills is expected to feature for John Longmire's side this weekend after overcoming an Achilles complaint.
Tall Joel Amrtey is continuing in his recuperation on course to return to match fitness, undergoing a separate training program this week.
The Eagles have already been dealt a major blow after star midfielder Tim Kelly tested positive to COVID, with the ex-Cat ruled out of Sunday's clash with the Suns.
