The Saints have been hit hard by injuries after Sunday's thumping loss to Adelaide, with injuries to McCartin, Dempster, Fisher and Riewoldt, while Freeman has also suffered another setback.

Defender Sean Dempster will miss the next 4-5 weeks due to a knee injury, which requires surgery.

"Sean Dempster won't play this week. He has a procedure on his knee and could miss the next four weeks. Along with Fisher," St Kilda football manager Jamie Cox said.

Sam Fisher will also miss 3-4 weeks, while luckless former Pie Nathan Freeman will miss up to four weeks after suffering yet another injury setback.

Meanwhile, young forward Paddy McCartin will not play this week after suffering a severe concussion on the weekend.

"Paddy certainly won't play this week given it's his second concussion for the year. His neck was cleared in hospital," Cox said.

"Concussion is certainly an area of the game where the awareness has improved. It's an area no one will take risks on."

St Kilda captain Nick Riewoldt is also in doubt for this week's clash with Carlton at Etihad Stadium due to a knee injury.

"Nick is 50/50 to play on the weekend. No structural damage. We'll find out later in the week," Cox said.

As reported on Monday, youngster Hugh Goddard will miss the rest of the season after rupturing his Achilles tendon.

More to come.

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