Collingwood forward Patrick Karnezis has retired from AFL after just 25 games, citing a desire to pursue interests outside of football.

The 23-year-old played 21 games for the Lions, before moving to Collingwood at the end of 2013.

"After five years in the AFL system, it is the right time for me to step away and pursue other interests in my life such as my studies, overseas travel and opportunities in our family businesses," Karnezis said.

"I want to thank Collingwood and Brisbane for the opportunity to play at the elite level, the experiences I've had at both clubs has helped shape the person I am today."